Penetrex Pain Relief Cream Review

We have reviewed hundreds of online Penetrex reviews across the web, Amazon, and stores and collected all the essential information you should know before using this pain-relief cream. Check the table of content below, and go to your point of interest.

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Pain, whether nerves, joints, tendons, muscles, back, neck, or elbow, can be very annoying and discomforting. If you suffer from this deliberating pain, you may have difficulty enjoying your daily activities or even walking and moving around easily.

Penetrex, Joint and Muscle therapy, claim to help you get instant and long-lasting pain relief and reduce its flare-up; whether it is arthritis, sciatica pain, neuropathy, repetitive strain, golf elbow, or sore neck, Penetrex is supposed to be your ultimate solution.

Nevertheless, does it help reverse muscle and joint pain and improve it over time? Read this in-depth Penetrex Joint & Muscle Therapy Review guide to find it if it is actually the best product or just a typical pain-relieving cream.

Quick Review

Product NamePenetrex Muscle & Joint Therapy
CategoryPain-relief Homeopathic Cream 
Manufacture Biomax Health Products, Inc. of San Diego, California
Indication Heel spurs, golf elbow, golfers elbow, tennis elbow, carpal tunnel syndrome, tendonitis, trigger finger, plantar fasciitis, RLS, sciatica, fibromyalgia, arthritis, shin splints, neuropathy, bursitis, sore back, sore neck, repetitive strain
Special Features ✅ Intensive concentration cream
✅ Natural ingredients 
✅ Paraben-free
✅ Disappearing scent
✅ Non-greasy
✅ Non-staining
✅ No freezing
✅ No burning
✅ Cruelty-free
Ingredients Arnica
Vitamin B6
MSM / DMSO2 Methylsulfonylmethane
Boswellia Serrata
Dosage FormCream and Gel
Direction To UseApply the product to the affected area and massage it gently until it absorbs into the skin.
Safety Information This product is only for external use. If you don’t understand how to use Penetrex, ask for a doctor’s help. Follow all the instructions mentioned in the Penetrex package.
Legal Disclaimer It is not intended to cure, diagnose, or prevent any disease. It is not evaluated by the FDA. 
Pricing The 2-Ounce Jar costs $18.98 The 4-Ounce Jar costs $34.95 The 3-Ounce Roll-On costs $24.95 
Where To Buy?Penetrex on Amazon
Penetrex on eBay

Penetrex Pros & Cons

✅ Made of natural ingredients ❌ Slow-acting 
✅ Trusted by over 2 million users❌ Reported cases of skin allergy (redness, skin rash)
✅ Non-greasy, non-staining, paraben-free, soothing cream, non-burning, non-freezing, no strong odor 
✅ Deeply penetrates at the discomfort area (Relief guarantee)
✅ Provides relief to a wide range of muscle and joint pains at a deeper level 
✅ It is cost-efficient 
✅ Ships worldwide
✅ Free delivery over the order of $35 (only in the USA)

What is the Penetrex Joint and Muscle Cream?

Penetrex pain relief therapy is a unique formulation of vegan and natural ingredients intended to soothe muscles and joint discomforts. According to Amazon, it is the #1 best-selling product in pain relieving creams. 

Penetrex comes in cream and roll-on gel containers, a proprietary blend of premium ingredients. It is the intensive-concentrated solution of vitamin B6, Arnica, MSM, Glucosamine, Choline, and many other components.

Penetrex pain-relief cream helps to provide deep and penetrating relief for hands, feet, neck, back, and whole body pain. You can use it to lower the symptoms of arthritis, stiff muscles, sciatica, neuropathy, and strains.

Penetrex Reviews: Ingredients, Comparison, Benefits, Side Effects
-Penetrex Product Line

Penetrex Pain Cream Uses: What Is Penetrex Cream Used For?

You can use Penetrex cream to relieve pain and discomfort throughout the body, including the neck, hands, foot, knee, toes, wrist, ankle, and elbow. 

Following are the conditions in which you can apply Penetrex pain relief products on the affected areas:

  • Sciatica 
  • Arthritis 
  • Heel spurs
  • Shin splints
  • Neuropathy
  • Golf elbow 
  • Golfers elbow 
  • Tennis elbow 
  • Carpal tunnel syndrome 
  • Tendonitis
  • Trigger finger 
  • Plantar fasciitis 
  • RLS 
  • Fibromyalgia 
  • Bursitis 
  • Sore back 
  • Sore neck 
  • Repetitive strain

Is Penetrex Cream Safe To Use?

Penetrex cream is safe to use on the external skin only. You can also use it with other pain-relieving kits such as heating pads, knee braces, supplements, massagers, etc. 

Although it is safe to use, it may cause skin rash or redness, which can be better on its own. Overall, it is a reliable and efficient product.

How Does it Work?

Penetrex Reviews: Ingredients, Comparison, Benefits, Side Effects

Penetrex cream contains anti-inflammatory and penetrating ingredients such as arnica, vitamin B6, and methylsulfonylmethane, which enter deeply into the skin and reduce inflammation in the affected areas, allowing for slow healing.

Furthermore, substances like capsaicin, pyridoxine, and Boswellia serrata modulate never transmission, blood circulation, and pain management, allowing for fast muscle or joint discomfort relief.

Penetrex Ingredients

Penetrex formula comes in two packages: a concentrated cream and a roll-on gel. Both packages’ chemical composition and ingredient list are nearly the same, but they may differ in some compounds.

Below is the complete list of Penetrex pain relief cream and Penetrex pain-relief gel: 


  • Water 
  • Arnica Montana Flower Extract 
  • Helianthus Annuus (Sunflower) Seed Oil 
  • Glycerin, Glyceryl Stearate 
  • PEG-100 Stearate
  • Cetyl Esters, Steareth-20 
  • Pyridoxine Hydrochloride (Vitamin B6)
  • Methylsulfonylmethane (MSM/DMSO2) 
  • Glucosamine (Vegetable Source)
  • Bilineurine Bitartrate
  • Ethoxydiglycol, Methyl Gluceth-20
  • Cetyl Myristoleate 
  • Aloe Barbadensis (Aloe Vera) Leaf Extract
  • Butyrospermum Parkii (Shea Butter) 
  • Boswellia Serrata (Frankincense) Oil 
  • Mentha Piperita (Peppermint) Oil 
  • Cinnamomum Camphora (Camphor)
  • Melaleuca Alternifolia (Tea Tree) Leaf Oil 
  • Tocopherol (vitamin E) 
  • Dipotassium Glycyrrhizinate 
  • Dimethicone
  • Ammonium Acryloyl-Dimethyltaurate/VP Copolymer 
  • Phenoxyethanol
  • DMDM Hydantoin 
  • Iodopropynyl Butylcarbamate


  • Water
  • Isopropyl Alcohol, Arnica Montana Flower Extract
  • Pyridoxine Hydrochloride 
  • Methylsulfonylmethane (MSM/DMSO2)
  • Glucosamine (vegetable source)
  • Bilineurine Bitartrate 
  • Ethoxydiglycol 
  • Cetyl Myristoleate
  • Aloe Barbadensis (Aloe Vera) Leaf Extract
  • Boswellia Serrata (Frankincense) Oil
  • Rosmarinus Officinalis (Rosemary) Oil
  • Juniperus Communis (Juniper Berry) Oil 
  • Mentha Piperita (Peppermint) Oil
  • Eucalyptus Globulus (Eucalyptus) Leaf Oil
  • Melaleuca Alternifolia (Tee Tree) Leaf Oil 
  • Cinnamomum Camphora (Camphor) 
  • Tocopherol (vitamin E) 
  • Dipotassium Glycyrrhizinate
  • Carbomer
  • Triethanolamine
  • DMDM Hydantoin 
  • Diazolidinyl Urea 
  • Iodopropynyl Butylcarbamate

Active Ingredients of Penetrex Review 

The makers of Penetrex claim that all of their products are clinically safe and have been scientifically proven to reduce inflammation and pain. Let’s take a look at Penetrex’s main active ingredients and how they work to relieve pain:


Arnica is a medicinal plant used for centuries in Europe to treat pain and inflammation. According to clinical research data, applying supplements containing arnica extracts substantially relaxes the affected areas (but the arnica tablets are ineffective for pain relief) (1)

Arnica extracts contain anti-inflammatory compounds, such as sesquiterpene lactones, phenolic acids, flavonoids, short-chain carbonic acid esters, carotenoids, essential oils, and oligosaccharides (2).

It has high potency to reduce osteoarthritis pain and improve physical function.

Vitamin B6

Vitamin B6, also known as pyridoxine, regulates sodium and potassium, which promotes nerve activity and regulates body fluids. Researchers have found that Vitamin B6 helps relieve the discomfort caused by repetitive muscular use (3).

MSM / DMSO2 Methylsulfonylmethane

Several studies have related methylsulfonylmethane to anti-inflammatory characteristics and potential sulfur contributions to connective tissue, which could explain why MSM is beneficial against muscular soreness. (4) (5) (6)

Furthermore, MSM has a unique ability to enter cells and tissues, consequently modifying physiological effects.

Aside from its potential therapeutic applications, MSM can also function as a carrier or co-transporter.

Boswellia Serrata

Boswellia serrata and its extracts are extremely beneficial in managing pain and stiffness and improving physical function. 

Penetrex includes the bark of this plant. This ingredient in Penetrex has potential anti-inflammatory agents, making it an effective pain-management and healing agent in any ointment or supplement (7) (8)

Moreover, the resin of this plant is naturally rich in Boswellic acids, which are believed to support blood circulation to the joints, muscles & bones and the health of connective tissues and blood vessels.


Capsaicin is a powerful anti-inflammatory and painkiller derived straight from chili peppers. This chemical is essential in lowering muscle and joint pain by inhibiting neurotransmitter activation (blocking the pain-producing transmitters).

This chemical is especially beneficial in reducing the discomfort, stiffness, and aches experienced by arthritis and sciatica patients. (9)

Potential Side Effects

Penetrex is generally safe to use on the external skin, but it may also cause mild reactions. 

  • Warmth
  • Irritation
  • Redness
  • Skin rash

Nevertheless, it is less likely to cause health risks or allergic reactions. However, if you experience a burning sensation, headache, dizziness, or swelling, discontinue its use and ask for expert advice.

What Do Other People Say?

Penetrex is a widely used and purchased pain-relieving topical ointment. It has a number of reviews on social media, health forums, Amazon, and on its official sites as well. Most of the Penetrex customers’ reviews are appreciative and recommended. 

For example on Amazon, Penetrex Reviews are more than 87.000 with a total rating score of 4.3 out of 5.

Penetrex Reviews on Amazon
– Penetrex Reviews on Amazon.

On eBay, Penetrex scores over 4.5 out of 5 from hundreds of reviewers as well.

Penetrex Reviews: Ingredients, Comparison, Benefits, Side Effects
– Penetrex Reviews on eBay.

For instance, one user said it is a miracle cream for me, as it provides sciatica pain relief much more efficiently than other creams. In contrast, others said it is highly easy to use, gives effective pain management results, is affordable, handy, and highly recommended. 

On the other hand, some users were also disappointed with its consistency (as it is a semi-liquid type, not a concentrated cream), allergic reaction, and not expected pain relief.

If you go and check the on star Penetrex reviews on Amazon you’ll find that there are alot of people (6% of the reviewers at the time of writing this review) that didn’t notice a thing. The pain was still persistent.

Well, I guess it depends on various factors whether the pain will be stay or go away. Anyway, the product has a 4.3 out of 5-star rating on Amazon; therefore, based on the rating, it is a product well received by the users. 

To close this section, check this honest Penetrex review from this guy on YouTube. There are hundreds of Penetrex Reviews on YouTube – most of them scam. This one though, is the read deal. Check it out.

Penetrex Review on YouTube.

How Does Penetrex Compare To Other Pain Relief Products?

To make this Penetrex Joint & Muscle Therapy review more complete, I’ve decided to compare Penetrex with other popular pain relief products currently in the market.

Product NameActive IngredientsOverall Review ScorePrice
PenetrexMethyl salicylate, menthol, methylsulfonylmethane (MSM)Positive$15-$30
Tiger BalmCamphor and mentholPositive$7-$10
Arnica GelArnica montanaPositive$10-$15
Australian DreamHistamine dihydrochloride, menthol, methyl salicylate, capsaicinPositive$15-$25
Penetrex Vs Voltaren, Tiger Balm, Biofreeze, Arnica Gel, Australian Dream

Where Can You Buy It?

Penetrex is available to purchase on the Penetrex official website, Amazon, CVS, iHerb, Walmart, and some local health stores.

All sites offer the original products at reasonable rates. Click on the below links from where you want to order or purchase Penetrex muscle and points therapy cream.

Bottom Line

As a result of my assessment of Penetrex Joint & Muscles therapy review, it is a decent and efficient product; however, it is slow acting.

You should not anticipate gaining relief after only one usage; instead, use it regularly for about 8 to 10 days to acquire adequate pain control.

After that, use it as needed. Furthermore, combining it with heating pads, cooling pads, or other supplements can help you manage your pain better.

DISCLAIMER: ''Content on this website is provided for information purposes only. Information about a therapy, service, product or treatment does not in any way endorse or support such therapy, service, product or treatment and is not intended to replace advice from your doctor or other registered health professional. The information and materials contained on this website are not intended to constitute a comprehensive guide concerning all aspects of the therapy, product or treatment described on the website. All users are urged to always seek advice from a registered health care professional for diagnosis and answers to their medical questions and to ascertain whether the particular therapy, service, product or treatment described on the website is suitable in their circumstances. shall not bear any liability for reliance by any user on the materials contained on this website.''

Penetrex Joint & Muscle Therapy Cream
Penetrex Reviews: Ingredients, Comparison, Benefits, Side Effects

Penetrex Joint & Pain Relief cream is a non-greasy, fast-acting cream for reducing joint and muscle pain, stiffness, and soreness. It contains a blend of ingredients such as methyl salicylate, menthol, and MSM, that are effective in reducing inflammation and promoting healing. People seem to love this product because you'll find thousand of 5 star reviews online. It's only drawback is that it is kind of expensive compared to other pain relievers in the market.

Product Brand: Penetrex Joint & Muscle Therapy Cream

Editor's Rating:


  • Positive Reviews around the web
  • Contains Natural Ingredients
  • It works


  • It's a bit expensive

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